Although studies had also shown that ERRγ was active in the brain, researchers didn't understand why - the brain burns sugar and ERRγ was previously shown to only burn fat. Thus, ERRγ became known as a master metabolic switch that energized muscle to enhance performance. ERRγ, they went on to show, turns on a whole host of muscle genes that convert fat to energy. In 2011, they discovered that promoting ERRγ activity in the muscle of sedentary mice increased blood supply to their muscles and doubled their running capacity. Evans' research group has previously studied the role of ERRγ in the heart and skeletal muscles. "The heart and muscles need a surge of energy to carry out exercise and neurons need a surge of energy to form new memories."Įnergy for muscles and brains, the scientists discovered, is controlled by a single protein called estrogen-related receptor gamma (ERRγ). "This is all about getting energy where it's needed to 'the power plants' in the body," says Ronald Evans, director of Salk's Gene Expression Laboratory and senior author of the new paper, published April 7, 2015. The new study could point to potential treatments in regenerative and developmental medicine as well as ways to address defects in learning and memory. Salk scientists and collaborators have discovered that physical and mental activities rely on a single metabolic protein that controls the flow of blood and nutrients throughout the body, as reported in the journal Cell Metabolism.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |